Welcome to the Pharmacogenomics Laboratory web site.

Research themes: Improving drug treatments and prognostic tools

Recent Lab News

08.2018

An excellent track record for research trainees in the Guillemette group at the Research Day of the Cancer Research Center

Yannick Audet-Delage, Ph.D. student, 1st prize for Best poster presentation by a Ph.D. student

Adrien Labriet, Ph.D. student, 3rd prize for Best talk by a Ph.D. student

Joanie Vaillancourt, M.Sc. student, Best poster presentation by an M.Sc. student

07.2018

Adrien Labriet, Ph.D. student, presented his most recent work at the 22nd ISSX North American meeting in Montréal, Canada. Adrien’s project was selected for an oral presentation, entitled RPL28 promoter polymorphism rs4806668 is associated with reduced survival in FOLFIRI-treated metastatic colorectal cancer patients.

Congratulations to Prof. Chantal Guillemette and Dr Eric Lévesque for their publication in collaboration with the group of Drs Paul Toren and Lawrence Klotz in Clinical Cancer Research entitled Serum sex steroids as prognostic biomarkers in patients receiving androgen deprivation therapy for recurrent prostate cancer: a post-hoc analysis of the PR.7 trial.

05.2018

Eric Allain, Ph.D. student, published his first paper on high Ph.D. project in Annals of Hematology entitled: Sex-dependent association of circulating sex steroids, pituitary hormones and treatment-free survival in patients with chronic lymphocytic leukemia. This study was conducted in collaboration with the research team of Prof. Katrina Vanura, Medical University of Vienna, Austria.

Eric also presented his work at the AACR Annual meeting 2018, held in Chicago.

Congratulations to Patrick Caron, chemist, and Chantal Guillemette for their work in collaboration with Michael B. Cook’s team, NIH, published in the Journal of the National Cancer Institute entitled Associations between Prediagnostic Levels of Circulating Sex Steroid Hormones and Esophageal/Gastric Cardia Adenocarcinoma.

04.2018

Great news for Adrien Labriet, Ph.D. student: Adrien was awarded a highly competitive Graduate student scholarship from the Fonds de recherche du Québec – Santé (FRQS) to pursue his Ph.D. project. Congratulations!

Adrien‘s work on colorectal cancer conducted in collaboration with the group of Dr Giuseppe Toffoli, CRO Aviano, Italy, was published in Frontiers in Pharmacology, entitled: Association of STAT-3 rs1053004 and VDR rs11574077 with FOLFIRI-related gastrointestinal toxicity in metastatic colorectal cancer patients.

Congratulations to Yannick Audet-Delage, Ph.D. student: Yannick received a travel award from the Metabolomics Society to attend the AACR annual meeting 2018.

Yannick presented his recent work at the AACR, entitled Metabolomics biomarkers for endometrial cancer and its recurrence after surgery in postmenopausal women.

This study was also published in Frontiers in Endocrinology, 9:87

Yannick also published in the Journal of Steroids and Biological Molecular Biology a second paper on his work on endometrial cancer entitled Estradiol Metabolites as Biomarkers of Endometrial Cancer Prognosis After Surgery.

Very well done Yannick!

03.2018

Joanie Vaillancourt, M.Sc. student, was awarded a Hydro-Québec excellence scholarship, for the Faculty of Pharmacy. Good news Joanie!

02.2018

The Guillemette’s group published novel findings on alternative variants of the main hepatic UGT2B10. Congratulations to Adrien Labriet, PhD student, and colleagues for their publication Posttranscriptional regulation of UGT2B10 hepatic expression and activity by alternative splicing in Drug Metabolism and Disposition.

12.2017
Congratulations to Adrien Labriet, Ph.D. student. Adrien was awarded the 1st prize for best poster presentation at the Scientific Day of the Endocrinology-Nephrology Axis, CHU de Québec.

11.2017
Great achievements for the research trainees in the Guillemette group at the Research Day of the Faculty of Pharmacy:

Yannick Audet-Delage, Ph.D. student, 1st prize for best talk by a Ph.D. student

Adrien Labriet, Ph.D. student, 1st prize for best poster presentation by a Ph.D. student

Eric Allain, Ph.D. student, 2nd prize for best poster presentation by a Ph.D. student

Sophie Anne Blanchet, summer student, 1st prize for best poster presentation by honors student

Congratulations to all!

10.2017
Congratulations to Eric Allain, Ph.D. student, for his George D. Smith Award received at the 13th Canadian CLL meeting in recognition for his excellence in CLL Research as a trainee.

Eric presented his most recent work in a talk entitled: Sex-dependent association of circulating hormones and treatment-free survival in patients with CLL

09.2017
The Ph.D candidate, Adrien Labriet, published his first paper with us in Frontiers Pharmacology, entitled:

Improved progression-free survival in metastatic colorectal cancer patients carriers of the HNF1A coding variant p.I27L treated with irinotecan

He presented this work at the 21st North American ISSX Meeting held in Providence, USA. http://www.issx2017na.com

07.2017
Dre Guillemette has been awarded $638,775 CND from CIHR for a 5-year research project entitled: Function of the glucuronosyltransferase pathway in chronic lymphocytic leukemia.  This work will be conducted in collaboration with Dr Éric Lévesque.

07.2017
Please view recent interviews given by Dr Chantal Guillemette and two of her graduate students (Eric Allain and Camille Girard-Bock), Faculty of Pharmacy, Laval University, about the research in the Pharmacogenomics group (in french).

https://youtu.be/Xgr1Hjij8dk

https://youtu.be/5TscnL_iw6Y

05.2017
Congratulations to Adrien Labriet, Ph.D. student, for winning the best poster presentation award at the Journées de la Recherche, Endocrinology-Nephrology axis, CHU de Québec.

Welcome to Joanie Vaillancourt, a new M.Sc. student in the Pharmacogenomics lab under the supervision of Dr Guillemette. Joanie was awarded a highly competitive studentship from the Fonds de recherché Santé-Québec. Congratulations Joanie!

04.2017
Quantitative profiling of the UGT transcriptome in human drug metabolizing tissues by Tourancheau A, Rouleau M, Milena-Guauque S, Villeneuve L, Gilbert I, Droit A, Guillemette C. Published in The Pharmacogenomics Journal.

The complex UGT alternative splicing programs have the strong potential to contribute to interindividual variability in drug metabolism in addition to diversify the UGT proteome.

02.2017
Rouleau M, Audet-Delage Y, Desjardins S, Rouleau M, Girard-Bock C, Guillemette C. Endogenous protein interactome of human UDP-glucuronosyltransferases exposed by untargeted proteomics. Published in Frontiers in Pharmacology.

Our work provides unprecedented evidence for a functional interaction between glucuronidation and other metabolic pathways.

01.2017
Audet-Delage Y, Rouleau M, Rouleau M, Roberge J, Miard S, Picard F, Têtu B and Guillemette C. Cross-talk between alternatively spliced UGT1A isoforms and colon cancer cell metabolism. Published in Molecular Pharmacology. Great job!