Welcome to the Pharmacogenomics Laboratory web site.

Research themes: Improving drug treatments and prognostic tools

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Recent Lab News

09.2017

The Ph.D candidate, Adrien Labriet, publishes his first paper with us in Frontiers Pharmacology, entitled:

Improved progression-free survival in metastatic colorectal cancer patients carriers of the HNF1A coding variant p.I27L treated with irinotecan

He will be presenting this work at the 21st North American ISSX Meeting held in Providence, USA. http://www.issx2017na.com

07.2017

Dre Guillemette has been awarded $638,775 CND from CIHR for a 5-year research project entitled: Function of the glucuronosyltransferase pathway in chronic lymphocytic leukemia.

07.2017

Please view recent interviews given by Dr Chantal Guillemette and two of her graduate students (Eric Allain and Camille Girard-Bock), Faculty of Pharmacy, Laval University, about the research in the Pharmacogenomics group (in french).

https://youtu.be/Xgr1Hjij8dk

https://youtu.be/5TscnL_iw6Y

05.2017

Congratulations to Adrien Labriet, Ph.D. student, for winning the best poster presentation award at the Journées de la Recherche, Endocrinology-Nephrology axis, CHU de Québec.

Dr Chantal Guillemette was awarded a Project grant from the Canadian Institutes of Health Research, to pursue the project entitled “Function of the glucuronosyltransferase pathway in chronic lymphocytic leukemia”. This work will be conducted in collaboration with Dr Éric Lévesque.

Welcome to Joanie Vaillancourt, a new M.Sc. student in the Pharmacogenomics lab under the supervision of Dr Guillemette. Joanie was awarded a highly competitive studentship from the Fonds de recherché Santé-Québec. Congratulations Joanie!

04.2017

Quantitative profiling of the UGT transcriptome in human drug metabolizing tissues by Tourancheau A, Rouleau M, Milena-Guauque S, Villeneuve L, Gilbert I, Droit A, Guillemette C. Published in The Pharmacogenomics Journal.

The complex UGT alternative splicing programs have the strong potential to contribute to interindividual variability in drug metabolism in addition to diversify the UGT proteome.

02.2017

Rouleau M, Audet-Delage Y, Desjardins S, Rouleau M, Girard-Bock C, Guillemette C. Endogenous protein interactome of human UDP-glucuronosyltransferases exposed by untargeted proteomics. Published in Frontiers in Pharmacology.

Our work provides unprecedented evidence for a functional interaction between glucuronidation and other metabolic pathways.

01.2017

Audet-Delage Y, Rouleau M, Rouleau M, Roberge J, Miard S, Picard F, Têtu B and Guillemette C. Cross-talk between alternatively spliced UGT1A isoforms and colon cancer cell metabolism. Published in Molecular Pharmacology. Great job!

12.2016

Congratulations to Camille Girard-Bock, Marie-Odile Benoit-Biancamano, Lyne Villeneuve, Sylvie Desjardins and Chantal Guillemette for their publication in Drug Metabolism and Disposition entitled “A rare UGT2B7 variant creates a novel N-glycosylation site at codon 121 with impaired enzyme activity”.

11.2016

Congratulations to Adrien Labriet and Yannick Audet-Delage, Ph.D. students in the Pharmacogenomics group. Adrien and Yannick each won the 1st prize in their respective group for best poster presentation by a Ph.D. student at the 16th Journée de la Recherche, Faculty of Pharmacy, Laval University.

Eric Allain, Ph.D. student was awarded the Excellence studentship Fernand Labrie from Desjardins Research and Innovation studentship/Fondation CHU de Québec. Congratulations Eric!

09.2016

Congratulations to Eric Allain, Ph.D. student, for winning the George D. Smith Award 2nd place at the 12th Canadian CLL meeting in recognition for his excellence in CLL Research as a trainee.

Congratulations to the Pharmacogenomics research group for publishing their recent work revealing the expansion of the UGT transcriptome and diversification of UGT functions in human tissues, in Cell Reports (http://www.cell.com/cell-reports/abstract/S2211-1247(16)31173-1).

This publication was highlighted in the September 29, 2016 issue of the Fil des Événements, Laval University
https://www.lefil.ulaval.ca/famille-pleine-expansion/

 

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The Leukemia and Lymphoma Society of Canada recently held their fund-raising campagn in Québec city. Dr Chantal Guillemette (second from left), Dr Eric Lévesque and Ph.D. student Eric Allain (not on this picture) were actively involved in the LIGHT THE NIGHT’WALK.

http://www.journaldequebec.com/2016/09/22/precieux-don-de-vie-dallemagne

08.2016
Congratulations to Eric Allain, Ph.D. student, for his Jury Award for Best PhD student poster presentation at the CRC Student Scientific Day 2016, Laval University.

07.2016
Sandra Guauque-Olarte, post-doctoral fellow in the Pharmacogenomics research group, has taken a Professor-Researcher position in the Faculty of Dentistry at the Universidad Cooperativa de Colombia (Pasto). Congratulations Sandra!

06.2016
Adrien Labriet, Ph.D. student, was awarded a studentship from the Fonds de l’enseignement et de la recherche (Laval University). Great news Adrien!

05.2016
Yannick Audet-Delage, Ph.D. student, received a travel award from the Metabolomics Society to attend the Informatics and Statistics for Metabolomics workshop.

Eric Allain, Ph.D. student, was selected to receive a registration award to attend the Bioinformatics for Cancer Genomics workshop.

04.2016
Welcome to Laurence Cambron-Fortin! Laurence, an experienced bioanalyst, joined the metabolomics group of the Pharmacogenomics Laboratory.

02.2016
Anais Belledant completed her Ph.D. studies with a solid thesis defense.  Congratulations Dr Belledant for your work and your Ph.D. degree, we wish you all the best with your future projects and career.