Welcome to the Pharmacogenomics Laboratory web site.

Research themes: Adapting medications to genetic and genomic profiles, and early detection and prevention of disease


Recent Lab News

Please view recent interviews given by Dr Chantal Guillemette and two of her graduate students (Eric Allain and Camille Girard-Bock), Faculty of Pharmacy, Laval University, about the research in the Pharmacogenomics group (in french).





Congratulations to the Pharmacogenomics research group for publishing their recent work revealing the expansion of the UGT transcriptome and diversification of UGT functions in human tissues, in Cell Reports (http://www.cell.com/cell-reports/abstract/S2211-1247(16)31173-1).

This publication was highlighted in the September 29, 2016 issue of the Fil des Événements, Laval University



The Leukemia and Lymphoma Society of Canada recently held their fund-raising campagn in Québec city. Dr Chantal Guillemette (second from left), Dr Eric Lévesque and Ph.D. student Eric Allain (not on this picture) were actively involved in the LIGHT THE NIGHT’WALK.


Congratulations to Eric Allain, Ph.D. student, for his Jury Award for Best PhD student poster presentation at the CRC Student Scientific Day 2016, Laval University.

Sandra Guauque-Olarte, post-doctoral fellow in the Pharmacogenomics research group, has taken a Professor-Researcher position in the Faculty of Dentistry at the Universidad Cooperativa de Colombia (Pasto). Congratulations Sandra!

Adrien Labriet, Ph.D. student, was awarded a studentship from the Fonds de l’enseignement et de la recherche (Laval University). Great news Adrien!

Yannick Audet-Delage, Ph.D. student, received a travel award from the Metabolomics Society to attend the Informatics and Statistics for Metabolomics workshop.

Eric Allain, Ph.D. student, was selected to receive a registration award to attend the Bioinformatics for Cancer Genomics workshop.

Welcome to Laurence Cambron-Fortin! Laurence, an experienced bioanalyst, joined the metabolomics group of the Pharmacogenomics Laboratory.

Anais Belledant completed her Ph.D. studies with a solid thesis defense.  Congratulations Dr Belledant for your work and your Ph.D. degree, we wish you all the best with your future projects and career.

Well done Guillaume Margaillan and Alan Tourancheau for your thesis defense. Congratulations to both of you for your Ph.D. degrees awarded by the Faculty of Pharmacy! We wish you all the best for your future careers!

The Bioanalytical group (Patrick Caron and Véronique Turcotte) directed by Dr Chantal Guillemette published their novel method enabling the simultaneous profiling of ten endogenous steroids in serum in Steroids. This important contribution will help preserving precious clinical samples from existing biobanks.

Eric Allain, Ph.D. student, was awarded a leadership et développement durable studentship from Laval University, for his remarkable contribution to social and humanitarian work. Way to go Eric!

Congratulations to Eric Allain, Ph.D. student, for his George D. Smith Award received at the 11th Canadian CLL meeting in recognition for his excellence in CLL Research as a trainee.

Adrien Labriet joined the Pharmacogenomics Lab as a new Ph.D. student under the supervision of Dr Chantal Guillemette. Welcome in the group Adrien!

Dr Guillemette contributed to the published CPIC guidelines for UGT1A1 and Atazanavir Prescribing, published in Clinical Pharmacology and Therapeutics. See also: https://www.pharmgkb.org/guideline/PA166128738

Welcome to Anne-Marie Duperré in the Metabolomics group of the Pharmacogenomics Lab.

Dr Chantal Guillemette has been invited to give a presentation at the 45th Gordon Research Conference on Drug Metabolism, New Hampshire, entitled « Splice Variants – Novel Regulators of UGT Function ».

Dr Guillemette was awarded an operating grant from the Canadian Institutes of Health Research to conduct the project entitled “Modulation of cell metabolism: Role of UDP-glucuronosyltransferase (UGT1A) proteins”.

Congratulations to Anais Belledant, Ph.D. student, Dr Chantal Guillemette, Dr Éric Lévesque, Dr Louis Lacombe and Dr Yves Fradet, for their manuscript accepted for publication in European Urology. This cornerstone study reveals the impact of the UGT2B28-steroid inactivation pathway on the concentrations of circulating androgen levels and on the risk of prostate cancer progression.

Dr Chantal Guillemette was awarded an operating grant from the Lymphoma and Leukemia Society of Canada, to pursue the project entitled “UGT2B17 in CLL: Functional consequences and therapeutic implications”. This project will be conducted in collaboration with Dr Éric Lévesque.

A Canadian Foundation for Innovation infrastructure grant was awarded to Dr Guillemette to acquire a mass spectrometer coupled to a liquid chromatography system (AB Sciex 6500) to conduct the analysis of small molecules (hormones and drugs) in a variety of biological material.

Yannick Audet-Delage, Ph.D. student, was awarded a highly competitive 3-year studentship from the Fonds de recherché Santé Québec. Very well done Yannick!

Eric Allain, Ph.D. student, was awarded a recruiting studentship from the Faculty of Pharmacy, U. Laval, for his outstanding academic track record. Congratulations Eric!

Congratulations to Alan Tourancheau, Ph.D. student, and the Guillemette research group for defining over 130 novel variants of human UGTs expressed in drug-metabolizing and hormone-dependent tissues by next-generation sequencing. This groundbreaking work is accepted for publication in The Pharmacogenomics Journal.

Chen S, Laverdiere I, Tourancheau A, Jonker D, Couture F, Cecchin E, Villeneuve L, Harvey M, Court MH, Innocenti F, Toffoli G, Lévesque E, Guillemette C.
A novel UGT1 marker associated with better tolerance against irinotecan-induced severe neutropenia in metastatic colorectal cancer patients.
Published in Pharmacogenomics Journal. Good Job !

Margaillan G, Rouleau M, Fallon JK, Caron P, Villeneuve L, Turcotte V, Smith PC, Joy MS, Guillemette C.
Quantitative Profiling of Human Renal UDP-glucuronosyltransferases and Glucuronidation Activity: A Comparison of Normal
and Tumoral Kidney Tissues.
Published in Drug Metabolism and Disposition. Congratulations for your excellent work !

Welcome to Eric Allain, a new Ph.D. student !!!