Michèle Rouleau, Ph.D

Adjunct professor and senior scientist
B.Sc. in Biochemistry, M.Sc. and Ph.D. in Molecular Biology

Joined in 2013

Nickname : Michou
Likes : coffee
Dislikes : car drivers that don’t respect cyclists, and cyclists that don’t respect car drivers

Email: michele.rouleau@crchudequebec.ulaval.ca

List of publications


Guillemette C, Lévesque É, Rouleau M. Pharmacogenomics of human uridine diphospho-glucuronosyltransferases and clinical implications. Clin Pharmacol Ther. 2014 Sep;96(3):324-39. Epub 2014 Jun 12.

Krietsch J., Rouleau M., Pic E., Ethier C., Dawson T.M., Dawson V.L., Masson J.Y., Poirier G.G., Gagné J.P. (2013) Reprogramming cellular events by poly(ADP-ribose)-binding proteins. Mol Aspects Med. 36, 1066-1087.

Krietsch J., Caron M.C., Gagné J.P., Ethier C., Vignard J., Vincent M., Rouleau M., Hendzel M.J., Poirier G.G., Masson J.Y. (2012) PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks. Nucleic Acids Res. 40, 10287-10301.

Gagné J.P., Rouleau M., Poirier G.G. (2012) Structural biology. PARP-1 activation–bringing the pieces together. Science 336, 678-679.

Rouleau M., Saxena V., Rodrigue A., Paquet E.R., Gagnon A., Hendzel M.J., Masson J.Y., Ekker M., Poirier G.G. (2011) A key role for poly(ADP-ribose) polymerase 3 in ectodermal specification and neural crest development. PLoS One 6, e15834.

Rouleau M., Patel A., Kaufmann S.H., Hendzel M.J. and Poirier G.G. (2010) PARP inhibition: PARP-1 and beyond. Nature Rev. Cancer 10, 293-301.

Rulten S.L., Fisher A.E., Robert I., Zuma M.C., Rouleau M., Ju L., Poirier G., Reina-San-Martin B., Caldecott K.W. (2011) PARP-3 and APLF function together to accelerate nonhomologous end-joining. Mol. Cell 41, 33-45.

Isabelle M., Moreel X., Gagné J.P., Rouleau M., Ethier C., Gagné P., Hendzel M.J., Poirier G.G. (2010) Investigation of PARP-1, PARP-2, and PARG interactomes by affinity-purification mass spectrometry. Proteome Sci. 8, 22.

Rouleau M., El-Alfy M., Lévesque M.-H. and Poirier, G.G. (2009) Assessment of PARP-3 distribution in tissues of adult cynomolgous monkeys. J Histochem. Cytochem. 57, 675-685.

Droit A., Hunter J.M., Rouleau M., Ethier C., Picard-Cloutier A., Bourgais D. and Poirier G.G. (2007) PARPs database: a LIMS systems for protein-protein interaction data mining or laboratory information management system. BMC Bioinformatics 8, 483.

Rouleau M., McDonald D., Gagné P., Ouellet M.-E., Droit A., Hunter J.M., Dutertre S., Prigent C., Hendzel M.J. and Poirier G.G. (2007) PARP-3 associates with polycomb group bodies and with components of the DNA damage repair machinery. J. Cell. Biochem. 100, 385-401.

Haince, J.F., Rouleau M., Poirier G.G. (2006) Transcription. Gene expression needs a break to unwind before carrying on. Science 312, 1752-1753.

Haince J.F., Rouleau M., Hendzel M.J., Masson J.Y. and Poirier G.G. (2005) Targeting poly(ADP-ribosyl)ation: a promising approach in cancer therapy. Trends Mol. Med. 11, 456-463.

Rouleau M., Aubin R.A. and Poirier GG. (2004) Poly(ADP-ribosyl)ated chromatin domains: Access granted. J. Cell Sci. 117, 815-825.

Rouleau M. and Poirier, G.G. (2004) Potential role of PARP inhibitors in cancer treatment and cell death In DNA Repair in Cancer Therapy, Panasci, L.C. and Alaoui-Jamali, M.A. eds., Humana Press: pp197-210.

Bouchard V.J., Rouleau M. and Poirier G.G. (2003). PARP-1, a determinant of cell survival in response to DNA damage. Exp. Hematol. 31, 446-454.

Larivière, B., Rouleau, M., Picard, S. and Beaulieu, A.D. (2003) Human plasma fibronectin potentiates the mitogenic activity of PDGF-BB and complements its wound healing effects. Wound Rep. Regen. 11, 79-89.

Richard, M., Veilleux, P., Rouleau, M., Paquin, R. and Beaulieu, A.D. (2002) The expression pattern of the ITIM-bearing lectin CLECSF6 in neutrophils suggests a key role in the control of inflammation. J. Leukoc. Biol. 71, 871-880.

Rouleau, M., Marsolais, F., Richard, M., Nicolle, L., Voigt B., Adam, G. and Varin, L. (1999) Inactivation of brassinosteroid biological activity by a salicylate-inducible steroid sulfotransferase from Brassica napus. J. Biol. Chem. 274, 20925-20930.

Varin, L., Marsolais, F., Richard, M., and Rouleau, M. (1997) Biochemistry and molecular biology of plant sulfotransferases. FASEB J. 11, 517-525.

Rouleau, M., Smith, R.J., Bancroft, J.B., and Mackie, G.A. (1995) Subcellular immuno-localization of the coat protein of two potexviruses in infected Chenopodium quinoa. Virology 214, 314-318.

Rouleau, M., Smith, R.J., Bancroft, J.B., and Mackie, G.A. (1994) Purification, properties and subcellular localization of foxtail mosaic potexvirus 26-kDa protein. Virology 204, 254-265.

Rouleau, M., Bancroft, J.B., and Mackie, G.A. (1993) Partial purification and characterization of foxtail mosaic potexvirus RNA-dependent RNA polymerase. Virology 197, 695-703.

White, K.A., Rouleau, M., Bancroft, J.B., and Mackie, G.A. (1993) Potexviruses. In Encylopedia of Virology, Webster, R.G. and Granoff, A., eds., Academic Press Ltd, San Diego, California, pp.1142-1147.

Bancroft, J.B., Rouleau, M., Johnston, R., Prins, L., and Mackie, G.A. (1991) The entire nucleotide sequence of foxtail mosaic virus RNA. J. Gen. Virol. 72, 2173-2181.

Rouleau, M., Léger, J.G., and Tenniswood, M.P.R. (1990) Ductal heterogeneity of cytokeratins, gene expression and cell death in the rat ventral prostate. Mol. Endocrinol. 4, 2003-2013.

Tenniswood, M.P.R., Montpetit, M.L., Léger, J.G., Pineault, J., and Rouleau, M. (1988) Epithelial-stromal interactions and cell death in the prostate. In The prostate as an endocrine gland ? », Ablin, R.J. and Farnsworth, W.E., eds., CRC Press, Boca Raton, Fla.