Congratulations to Adrien Labriet, Ph.D. student. Adrien was awarded the 1st prize for best poster presentation at the Scientific Day of the Endocrinology-Nephrology Axis, CHU de Québec.
Great achievements for the research trainees in the Guillemette group at the Research Day of the Faculty of Pharmacy:
Yannick Audet-Delage, Ph.D. student, 1st prize for best talk by a Ph.D. student
Adrien Labriet, Ph.D. student, 1st prize for best poster presentation by a Ph.D. student
Eric Allain, Ph.D. student, 2nd prize for best poster presentation by a Ph.D. student
Sophie Anne Blanchet, summer student, 1st prize for best poster presentation by honors student
Congratulations to all!
Congratulations to Eric Allain, Ph.D. student, for his George D. Smith Award received at the 13th Canadian CLL meeting in recognition for his excellence in CLL Research as a trainee.
Eric presented his most recent work in a talk entitled: Sex-dependent association of circulating hormones and treatment-free survival in patients with CLL
The Ph.D candidate, Adrien Labriet, published his first paper with us in Frontiers Pharmacology, entitled:
He presented this work at the 21st North American ISSX Meeting held in Providence, USA. http://www.issx2017na.com
Dre Guillemette has been awarded $638,775 CND from CIHR for a 5-year research project entitled: Function of the glucuronosyltransferase pathway in chronic lymphocytic leukemia. This work will be conducted in collaboration with Dr Éric Lévesque.
Please view recent interviews given by Dr Chantal Guillemette and two of her graduate students (Eric Allain and Camille Girard-Bock), Faculty of Pharmacy, Laval University, about the research in the Pharmacogenomics group (in french).
Congratulations to Adrien Labriet, Ph.D. student, for winning the best poster presentation award at the Journées de la Recherche, Endocrinology-Nephrology axis, CHU de Québec.
Welcome to Joanie Vaillancourt, a new M.Sc. student in the Pharmacogenomics lab under the supervision of Dr Guillemette. Joanie was awarded a highly competitive studentship from the Fonds de recherché Santé-Québec. Congratulations Joanie!
Quantitative profiling of the UGT transcriptome in human drug metabolizing tissues by Tourancheau A, Rouleau M, Milena-Guauque S, Villeneuve L, Gilbert I, Droit A, Guillemette C. Published in The Pharmacogenomics Journal.
The complex UGT alternative splicing programs have the strong potential to contribute to interindividual variability in drug metabolism in addition to diversify the UGT proteome.
Rouleau M, Audet-Delage Y, Desjardins S, Rouleau M, Girard-Bock C, Guillemette C. Endogenous protein interactome of human UDP-glucuronosyltransferases exposed by untargeted proteomics. Published in Frontiers in Pharmacology.
Our work provides unprecedented evidence for a functional interaction between glucuronidation and other metabolic pathways.
Audet-Delage Y, Rouleau M, Rouleau M, Roberge J, Miard S, Picard F, Têtu B and Guillemette C. Cross-talk between alternatively spliced UGT1A isoforms and colon cancer cell metabolism. Published in Molecular Pharmacology. Great job!
Congratulations to Camille Girard-Bock, Marie-Odile Benoit-Biancamano, Lyne Villeneuve, Sylvie Desjardins and Chantal Guillemette for their publication in Drug Metabolism and Disposition entitled “A rare UGT2B7 variant creates a novel N-glycosylation site at codon 121 with impaired enzyme activity”.
Congratulations to Adrien Labriet and Yannick Audet-Delage, Ph.D. students in the Pharmacogenomics group. Adrien and Yannick each won the 1st prize in their respective group for best poster presentation by a Ph.D. student at the 16th Journée de la Recherche, Faculty of Pharmacy, Laval University.
Eric Allain, Ph.D. student was awarded the Excellence studentship Fernand Labrie from Desjardins Research and Innovation studentship/Fondation CHU de Québec. Congratulations Eric!
Congratulations to Eric Allain, Ph.D. student, for winning the George D. Smith Award 2nd place at the 12th Canadian CLL meeting in recognition for his excellence in CLL Research as a trainee.
Congratulations to the Pharmacogenomics research group for publishing their recent work revealing the expansion of the UGT transcriptome and diversification of UGT functions in human tissues, in Cell Reports (http://www.cell.com/cell-reports/abstract/S2211-1247(16)31173-1).
This publication was highlighted in the September 29, 2016 issue of the Fil des Événements, Laval University
The Leukemia and Lymphoma Society of Canada recently held their fund-raising campagn in Québec city. Dr Chantal Guillemette (second from left), Dr Eric Lévesque and Ph.D. student Eric Allain (not on this picture) were actively involved in the LIGHT THE NIGHT’WALK.
Congratulations to Eric Allain, Ph.D. student, for his Jury Award for Best PhD student poster presentation at the CRC Student Scientific Day 2016, Laval University.
Sandra Guauque-Olarte, post-doctoral fellow in the Pharmacogenomics research group, has taken a Professor-Researcher position in the Faculty of Dentistry at the Universidad Cooperativa de Colombia (Pasto). Congratulations Sandra!
Adrien Labriet, Ph.D. student, was awarded a studentship from the Fonds de l’enseignement et de la recherche (Laval University). Great news Adrien!
Yannick Audet-Delage, Ph.D. student, received a travel award from the Metabolomics Society to attend the Informatics and Statistics for Metabolomics workshop.
Eric Allain, Ph.D. student, was selected to receive a registration award to attend the Bioinformatics for Cancer Genomics workshop.
Welcome to Laurence Cambron-Fortin! Laurence, an experienced bioanalyst, joined the metabolomics group of the Pharmacogenomics Laboratory.
Anais Belledant completed her Ph.D. studies with a solid thesis defense. Congratulations Dr Belledant for your work and your Ph.D. degree, we wish you all the best with your future projects and career.
Well done Guillaume Margaillan and Alan Tourancheau for your thesis defense. Congratulations to both of you for your Ph.D. degrees awarded by the Faculty of Pharmacy! We wish you all the best for your future careers!
The Bioanalytical group (Patrick Caron and Véronique Turcotte) directed by Dr Chantal Guillemette published their novel method enabling the simultaneous profiling of ten endogenous steroids in serum in Steroids. This important contribution will help preserving precious clinical samples from existing biobanks.
Eric Allain, Ph.D. student, was awarded a leadership et développement durable studentship from Laval University, for his remarkable contribution to social and humanitarian work. Way to go Eric!
Congratulations to Eric Allain, Ph.D. student, for his George D. Smith Award received at the 11th Canadian CLL meeting in recognition for his excellence in CLL Research as a trainee.
Adrien Labriet joined the Pharmacogenomics Lab as a new Ph.D. student under the supervision of Dr Chantal Guillemette. Welcome in the group Adrien!
Dr Guillemette contributed to the published CPIC guidelines for UGT1A1 and Atazanavir Prescribing, published in Clinical Pharmacology and Therapeutics. See also: https://www.pharmgkb.org/guideline/PA166128738
Dr Chantal Guillemette has been invited to give a presentation at the 45th Gordon Research Conference on Drug Metabolism, New Hampshire, entitled « Splice Variants – Novel Regulators of UGT Function ».
Dr Guillemette was awarded an operating grant from the Canadian Institutes of Health Research to conduct the project entitled “Modulation of cell metabolism: Role of UDP-glucuronosyltransferase (UGT1A) proteins”.
Congratulations to Anais Belledant, Ph.D. student, Dr Chantal Guillemette, Dr Éric Lévesque, Dr Louis Lacombe and Dr Yves Fradet, for their manuscript accepted for publication in European Urology. This cornerstone study reveals the impact of the UGT2B28-steroid inactivation pathway on the concentrations of circulating androgen levels and on the risk of prostate cancer progression.
Dr Chantal Guillemette was awarded an operating grant from the Lymphoma and Leukemia Society of Canada, to pursue the project entitled “UGT2B17 in CLL: Functional consequences and therapeutic implications”. This project will be conducted in collaboration with Dr Éric Lévesque.
A Canadian Foundation for Innovation infrastructure grant was awarded to Dr Guillemette to acquire a mass spectrometer coupled to a liquid chromatography system (AB Sciex 6500) to conduct the analysis of small molecules (hormones and drugs) in a variety of biological material.
Yannick Audet-Delage, Ph.D. student, was awarded a highly competitive 3-year studentship from the Fonds de recherché Santé Québec. Very well done Yannick!
Eric Allain, Ph.D. student, was awarded a recruiting studentship from the Faculty of Pharmacy, U. Laval, for his outstanding academic track record. Congratulations Eric!
Congratulations to Alan Tourancheau, Ph.D. student, and the Guillemette research group for defining over 130 novel variants of human UGTs expressed in drug-metabolizing and hormone-dependent tissues by next-generation sequencing. This groundbreaking work is accepted for publication in The Pharmacogenomics Journal.
Chen S, Laverdiere I, Tourancheau A, Jonker D, Couture F, Cecchin E, Villeneuve L, Harvey M, Court MH, Innocenti F, Toffoli G, Lévesque E, Guillemette C.
A novel UGT1 marker associated with better tolerance against irinotecan-induced severe neutropenia in metastatic colorectal cancer patients.
Published in Pharmacogenomics Journal. Good Job !
Margaillan G, Rouleau M, Fallon JK, Caron P, Villeneuve L, Turcotte V, Smith PC, Joy MS, Guillemette C.
Quantitative Profiling of Human Renal UDP-glucuronosyltransferases and Glucuronidation Activity: A Comparison of Normal
and Tumoral Kidney Tissues.
Published in Drug Metabolism and Disposition. Congratulations for your excellent work !
Welcome to Eric Allain, a new Ph.D. student !!!
Laverdiere I, Flageole C, Audet-Walsh E, Caron P, Fradet Y, Lacombe L, Levesque E, Guillemette C.
The UGT1 locus is a determinant of prostate cancer recurrence after prostatectomy.
Published in Endocrine-Related Cancer. Congratulations for your excellent work !
Laverdière I, Guillemette C, Tamouza R, Loiseau P, Peffault de Latour R, Robin M, Couture F, Filion A, Lalancette M, Tourancheau A, Charron D, Socié G, Lévesque E.
Cyclosporin and methotrexate-related pharmacogenomics predictors of acute graft-vs-host disease.
Published in Haematologica. Good Job !!
Two Cancer Research Society (CRS) grants to Dr Chantal Guillemette, CRC in Pharmacogenomics, Laval University
Project 1: Function and regulation of a novel metabolic pathway associated with prognosis and drug resistance in chronic lymphocytic leukemia (CLL). The research will serve to better understand the function of a novel prognostic marker in CLL discovered by her group, as well as its role in resistance to anti-cancer therapy and as a new therapeutic target of CLL. This project is performed in collaboration with Dr Éric Lévesque (hemato-oncologist and Ph.D.) from Laval University, Faculty of medicine.
Project 2: Targeted metabolomics to discover novel biomarkers of uterine cancer. The project aims to identify novel blood-based biomarkers (detection of small-molecular-weight substances by mass spectrometry) of endometrial cancer that may reflect cancer occurrence, molecular characteristics and potential progression of disease. This project is performed in collaboration with Dr Jean Grégoire (gyneco-oncologist) from Laval University, Faculty of medicine.
Yannick Audet-Delage was a finalist for the graduate student poster award Hans Seyle at the 56th annual CRCQ meeting held in Ste-Adèle, QC.
Welcome to Camille Girard-Bock, a new M.Sc. student.
Welcome to Luciana Garcia-Pereira, a new M.Sc. student with Dr. Lévesque !!!.
Mélanie Rouleau received her Ph.D. degree from the Faculty of Pharmacy. Dre Rouleau, congratulations for your great work honored by the Faculté des études supérieures de l’Université Laval – Tableau d’honneur 2014 (Honnor roll). Good luck with your career!
Congratulations to Isabelle Laverdière for her superb thesis defense and Ph.D. degree awarded by the Faculty of Pharmacy! Dre Laverdière, we wish you all the best for your post-doctoral fellowship at McGill, and your future promising career!
Guillemette C, Lévesque E, Rouleau M.
Pharmacogenomics of human uridine diphospho-glucuronosyltransferases and clinical implications. Key review published in Clinical Pharmacology and Therapeutics.
Anne-Marie Duperré continues as a M. Sc. student in Dr Guillemette’s research group. Welcome Anne-Marie!
Drs Guillemette and Levesque in the news:
Eric Lévesque, Isabelle Laverdière, Etienne Audet-Walsh, Patrick Caron, Mélanie Rouleau, Yves Fradet, Louis Lacombe and Chantal Guillemette published their work entitled “Steroidogenic Germline Polymorphism Predictors of Prostate Cancer Progression in the Estradiol Pathway” in Clinical Cancer Research. Congratulations for your excellent work !
Anne-Marie Duperré joined the lab as an undergraduate student. Welcome!
Welcome to Yannick Audet-Delage, a new Ph.D. student!
Vincent received his Ph.D. degree from the faculty of Pharmacy. Congratulations Dr Ménard !!! We wish you the best for your new career!
Éric Lévesque, Isabelle Laverdière, Louis Lacombe, Patrick Caron, Mélanie Rouleau, Véronique Turcotte, Bernard Têtu, Yves Fradet and Chantal Guillemette published their work entitled “Importance of 5α-reductase gene polymorphisms on circulating and intraprostatic androgens in prostate cancer” in Clinical Cancer Research. Good Work !!
Andréa Fournier joined the team as a lab assistant – cell culture specialist. Welcome Andréa!!!
Vincent Ménard, Pierre Collin, Guillaume Margaillan and Chantal Guillemette published their work entitled “Modulation of the UGT2B7 enzyme activity by C-terminally truncated proteins derived from alternative splicing” in Drug Metabolism and Disposition. Nice Work !!!
Mélanie Rouleau, Joannie Roberge, Judith Bellemare and Chantal Guillemette published their work entitled “Dual Role for Splice Variants of the Glucuronidation Pathway as Regulators of Cellular Metabolism” in Molecular Pharmacology. Good job!
Mélanie Rouleau and Isabelle Laverdière respectively won the first and second prize for best pre-doctoral poster award at the 10th International ISSX Meeting held in Toronto. Congratulations to both of you!
Vincent Ménard, Eric Lévesque, Sylvia Chen, Olivier Eap, Melanie Joy, Lena Ekström, Anders Rane and Chantal Guillemette published their work entitled “Expression of UGT2B7 is driven by two mutually exclusive promoters and alternative splicing in human tissues: changes from prenatal life to adulthood and in kidney cancer” in Pharmacogenetics and Genomics. Congratulations!
Melanie Rouleau was finalist for the graduate student poster award Hans Selye at the 55th annual Meeting of CRCQ held in Québec. Nice work!
Michèle Rouleau joined the lab as an Adjunct professor and senior scientist. Welcome Michèle!
Dr Eric Lévesque is awarded FRSQ Clinician Scientist – Junior 2 (salary support) for its project entitled « Identification of Novel Prognostic Biomarkers in Stem cell Transplantation and Prostate Cancer ». Congratulations!
Isabelle Laverdière was awarded a Doctoral Training studentship award (category health professional) from the FRSQ. She ranked first!
Congratulations Isabelle !
Dr Eric Lévesque is awarded CIHR Clinician Scientist – Phase 2 for its project entitled « Identification of Novel Prognostic Biomarkers in Stem cell Transplantation and Prostate Cancer ». This 180 000 $ award is for 3 years.
Eric Lévesque, Anne-Sophie Bélanger, Mario Harvey, Félix Couture, Derek Jonker, Federico Innocenti, Erica Cecchin, Giuseppe Toffoli and Chantal Guillemette published their work entitled « Refining the UGT1A Haplotype Associated with Irinotecan-Induced Hematological Toxicity in Metastatic Colorectal Cancer Patients Treated with 5-Fluorouracil/Irinotecan-Based Regimens » in Journal of Pharmacology and Experimental Therapeutics. Congratulations!
Mélanie Rouleau, Pierre Collin, Judith Bellemare, Mario Harvey and Chantal Guillemette published their work entitled » Protein-protein interactions between the bilirubin-conjugating UDP-glucuronosyltransferase UGT1A1 and its shorter isoform 2 regulatory partner derived from alternative splicing » in Biochemical Journal. Excellent contribution!
Mélanie Rouleau, Joannie Roberge, Sarah-Ann Falardeau, Lyne Villeneuve and Chantal Guillemette published their work entitled « The Relative Protein Abundance of UGT1A Alternative Splice Variants as a Key Determinant of Glucuronidation Activity In Vitro » in Drug Metabolism and Disposition. Nice work !
Dr Éric Lévesque is one of the four recipients of the inaugural Movember-funded Rising Star in Prostate Cancer Research awards. These Canadian investigators represent the next generation of leading prostate cancer researchers across Canada. This award totalizes $150,000 per year ($75,000 for salary support and $75,000 for research expenses) for up to 3 years.
Welcome to Anais Belledant, Guillaume Margaillan and Alan Tourancheau, three new PhD students!!
Dr Guillemette in the news : http://www.fmed.ulaval.ca/site_fac/faculte/actualites/detail-de-l-actualite/un-nouveau-marqueur-pour-la-leucemie/
Éric Lévesque, Shu-Pin Huang, Étienne Audet-Walsh, Louis Lacombe, Bo-Ying Bao, Yves Fradet, Isabelle Laverdière, Mélanie Rouleau, Chao-Yuan Huang, Chia-Cheng Yu, Patrick Caron, Chantal Guillemette published their work entitled « Molecular markers in key steroidogenic pathways, circulating steroid levels, and prostate cancer progression » in Clinical Cancer Research. Great work !
Sylvia Chen was awarded a FER award. Congratulations!
Welcome to Isabelle Gilbert, a new post-doc student!
Welcome to Sylvia Chen, a new PhD student!
Etienne received his Ph.D. degree with Honors from the faculty of Pharmacy, having successfully defended his thesis last July. He is now a post-doc in Dr Vincent Giguère’s team at McGill University. Wishing you a successful career Etienne!
Welcome to Sindy Magnan, a master degree student with Dr Lévesque!
Isabelle Laverdière was awarded Canada Graduate Scholarships (Doctoral research award) from the Canadian Institutes of Health Research (CIHR). Congratulations!
Dr Guillemette in the news :
Pierre Collin was awarded FRSQ (Québec province) Graduate Scholarships- Master’s Awards. Congratulations!
Dr Guillemette in the news :
Pierre Collin was awarded the Hydro-Québec award as one of the promising Master degree candidates for 2010-2011. Congratulations!
Dr Guillemette in the news :
Isabelle Laverdière, Patrick Caron, Félix Couture, Eric Lévesque and Chantal Guillemette published their work entitled « A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for monitoring drug exposure in hematopoietic stem cell transplant recipients » in Journal of Chromatography B. Congratulations for your excellent work !
Sarah-Ann Falardeau joined the lab as an undergraduate student. Welcome!
Étienne Audet-Walsh, Judith Bellemare, Louis Lacombe, Yves Fradet, Vincent Fradet, Pierre Douville, Chantal Guillemette, and Éric Lévesque published their work entitled: « The Impact of Germline Genetic Variations in Hydroxysteroid (17-Beta) Dehydrogenases on Prostate Cancer Outcomes After Prostatectomy » in European Urology and had been the subject of an editorial as a platinum priority. Congratulations!
Isabelle Laverdière, Patrick Caron, Félix Couture, Chantal Guillemette and Eric Lévesque published their work entitled « Liquid chromatography-coupled tandem mass spectrometry based assay to evaluate inosine-5′-monophosphate dehydrogenase activity in peripheral blood mononuclear cells from stem cell transplant recipients » in Analytical Chemistry. Great work !
Dr Guillemette in the news:
Vincent Ménard, Olivier Eap, Joannie Roberge, Mario Harvey, Eric Lévesque and Chantal Guillemette published their work entitled » Transcriptional diversity at the UGT2B7 locus is dictated by extensive pre-mRNA splicing mechanisms that give rise to multiple mRNA splice variants » in Pharmacogenetics and Genomics. Congratulations everyone for your contribution !
Geneviève Nadeau, Judith Bellemare, Étienne Audet-Walsh, Christine Flageole, Shu-Pin Huang, Bo-Ying Bao, Pierre Douville, Patrick Caron, Yves Fradet, Louis Lacombe, Chantal Guillemette and Eric Lévesque published their work entitled « Deletions of the androgen-metabolizing UGT2B genes have an effect on circulating steroid levels and biochemical recurrence after radical prostatectomy in localized prostate cancer » in The Journal of Clinical Endocrinology & Metabolism. Good work !
Etienne Audet-Walsh, Judith Bellemare, Geneviève Nadeau, Louis Lacombe, Yves Fradet, Vincent Fradet, Shu-Pin Huang, Bo-Ying Bao, Pierre Douville, Hugo Girard, Chantal Guillemette and Eric Lévesque published their work entitled « SRD5A polymorphisms and biochemical failure after radical prostatectomy » in Enropean Urology. Very nice piece of work!
Mélanie Rouleau was awarded Canada Graduate Scholarships (Doctoral research award) from the Canadian Institutes of Health Research (CIHR). Congratulations!
Isabelle Laverdière, Patrick Caron, Mario Harvey, Éric Lévesque and Chantal Guillemette published their work entitled « In vitro investigation of human UDP-glucuronosyltransferase isoforms responsible for tacrolimus glucuronidation: predominant contribution of UGT1A4 » in Drug Metabolism and Disposition. Nice work !
Joannie Roberge was awarded the Hydro-Québec award for being one of the best CIHR Master degree candidates for the years 2010-2011. Congratulations for your award Joannie!
Étienne Audet-Walsh, Johanie Lépine, Jean Grégoire, Marie Plante, Patrick Caron, Bernard Têtu, Pierre Ayotte, Jacques Brisson, Lyne Villeneuve, Alain Bélanger and Chantal Guillemette published their work entitled: « Profiling of endogenous Estrogens, Their Precursors, and Metabolites in Endometrial Cancer Patients: Association with Risk and Relationship to Clinical Characteristics. » in Journal of Clinical Endocrinology and Metabolism – good work everyone!
Joannie Roberge was awarded the Frederick Banting and Charles Best Canada Graduate Scholarships from CIHR – Master’s Awards and a FRSQ (Québec province) Graduate Scholarships (Master research award). Congratulations!
Étienne Audet-Walsh and Vincent Ménard won the first prize in the Health Sciences category at the Contest « Mon Idée » at Laval University on November 24. Good job guys !
Judith Bellemare, Mélanie Rouleau, Hugo Girard, Mario Harvey and Chantal Guillemette published their work entitled « Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro » published in Drug Metabolism and Disposition. Nice work!
Judith had her final thesis defense examination october 14, 2010. She is now a Ph.D. and got her degree with Honors from the faculty of Pharmacy. Congratulations Dr. Bellemare !!!
Judith Bellemare, Mélanie Rouleau, Mario Harvey, Ion Popa, Georges Pelletier, Bernard TÍtu and Chantal Guillemette recently published their work entitled « Immunohistochemical expression of conjugating UGT1A-derived isoforms in normal and tumoral drug-metabolizing tissues in humans » published in Journal of Pathology. Congratulations for your good work!
For the Endocrinology and Genomics Research Axis and CREMOGH scientific meeting, the students invited the 1993 Nobel Prize in Physiology or Medicine laureat Dr. Phillip A. Sharp for a presentation on RNA biology. The students had also the privilege to have a Q&A with Dr.Sharp.
For this journey all the students from the research center presented their work to the member of the Endocrinology and Genomics Research Axis and CREMOGH.
Members of LaboCG did great at the presentation competition and were awarded for the excellence of their work:
– Judith was awarded the best oral presentation and the people choice.
– Melanie was awarded the best poster presentation by a doctoral student.
– Christine was awarded the best poster presentation by a master student.
Post-Doctoralstudent Nathalie Amiable joined the team. WelcomeNathalie !
Mélanie Rouleauwas awarded FRSQ (Québec province) Graduate Scholarships (Doctoral research award). Congratulations!
Christine Flageole was awarded the Frederick Banting and Charles Best Canada Graduate Scholarships from CIHR – Master’s Awards. Congratulations!
Undergraduate student Pierre Colin was awarded FER (Université Laval) trainee scholarship Congratulations!
Graduate student Joannie Roberge was awarded FER (Université Laval) graduate scholarship (Master degree award). Congratulations!
Welcome to Pierre Collin, an undergraduate student from Laval University, who will be working full time with us this summer.
Anne-Sophie had her final thesis defense examination March 11, 2010. She is now a Ph.D. and got her degree from the faculty of Pharmacy. Congratulations Dre. Bélanger ! We wish you the best for your new career !
Éric Lévesque, Vincent Ménard, Isabelle Laverdière, Judith Bellemare, Olivier Barbier, Hugo Girard et Chantal Guillemette published their work entitled: « Extensive splicing of transcripts encoding the bile acid-conjugating enzyme UGT2B4 modulates glucuronidation. » in the Journal of Pharmacogenetics Genomics. Congratulations !
Anne-Sophie Belanger, Jelena Tojcic, Mario Harvey et Chantal Guillemette published their work entitled: « Regulation of UGT1A1 and HNF1 transcription factor gene expression by DNA methylation in colon cancer cells. » in BMC Molecular Biology. Nice work !
Congratulation to Geneviève Nadeau for her prize « Best poster » for her work entitled « Copy Number Variation of Sex-Steroid Metabolizing Genes as Biomarkers of Prostate Cancer Recurrence after Prostatectomy: Looking at the End of the Androgenic Signal » presented at the Society of Urologic Oncology Annual Meeting, Bethesda, Decembre 3-5, 2009.
Congratulations also to all the co-authors of the work Bellemare J., Douville P., Meyer F., Fradet Y., Guillemette C., Lacombe L. et Lévesque É. Good work everybody!
Judith Bellemare, Mélanie Rouleau, Mario Harvey, Bernard Têtuet ChantalGuillemette published their work entitled : »Alternative-splicing forms of the major phase II conjugating UGT1A gene negatively regulate glucuronidation in human carcinoma cell lines. » in The Pharmacogenomics Journal. 2009 Dec 8. Good work!
Judith Bellemare, Mélanie Rouleau, Mario Harvey et ChantalGuillemette published their work entitled: « The modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein interactions. » in the Journal ofBiological Chemistry, 2009 Dec 8. Congratulations !
Patrick Caron, Étienne Audet-Walsh, Johanie Lépine, Alain Bélanger and Chantal Guillemette published their work entitled : « Profiling Endogenous Serum Estrogen and Estrogen-Glucuronides by Liquid Chromatography-Tandem Mass Spectrometry » in Analytical Chemistry, 2009 Nov 16. Excellent!
Marie-Odile Benoît-Biancamano, Jean-Philippe Adam, Oliver Bernard, Patrick Caron and Chantal Guillemette published their work entitled : « A pharmacogenetics study of the human glucuronosyltransferase UGT1A4 » in Pharmacogenetics and Genomics, 2009 Nov 3. Good work!
Jelena Tojcic, Marie-Odile Benoît-biancamano, Patrick Caron and Chantal Guillemette published their work entitled « In vitro glucuronidation of fenofibric acid by human UDP-glucuronosyltransferases and liver microsomes » in Drug Metabolism and Disposition, 2009 Nov;37(11):2236-43. Nice work!
Graduate students Mélanie Rouleau was awarded CRSNG (Canada) graduate scholarship (Master degree award). Congratulations!
Congratulations to all members of the lab on their recent review on UGT published by Chantal Guillemette, Éric Lévesque, Mario Harvey, Judith Bellemare and Vincent Ménard entitled « UGT genomic diversity: beyond gene duplication » in Drug Metabolism Review, 2009
Dr. Chantal Guillemette was awarded the 2009 North American ISSX New Investigator Award in honor of James R. Gillette at the 16th North American ISSX Meeting- Baltimore, Maryland– October 18-22, 2009.
Judith Bellemare presented her work on the alternative splicing regulation of the UGT1A locus in native human cells at the 16th North American ISSX Meeting- Baltimore, Maryland– October 18-22, 2009.
Vincent Ménard, Olivier Eap, Mario Harvey, Chantal Guillemette and Éric Lévesque published their work entitled « Copy-number variations (CNVs) of the human sex steroid metabolizing genes UGT2B17 and UGT2B28 and their associations with a UGT2B15 functional polymorphism » in Human Mutation, 2009 Sep;30(9):1310-9. Congratulations!
Kim Journault joined the team as a lab assistant. Welcome back Kim !
Graduate student Judith Bellemare won the 1st place in the graduate student poster award competition at the 11th European Regional ISSX Meeting in Lisbon, Portugal, May 17-20, 2009, with her poster “Functional co-expression of UGT1 alternative splice isoforms and evidence of protein-protein interaction”. Congratulations!
Anne-Sophie, Patrick and Mario published their work of the antiretroviral efavirenz. Anne-Sophie Bélanger, Patrick Caron, Mario Harvey, Peter A. Zimmerman, Rajeev K. Mehlotra and Chantal Guillemette; Glucuronidation of the antiretroviral efavirenz (EFZ) by UGT2B7 and an in vitro investigation of drug-drug interaction with zidovudin (AZT); Drug Metab Dispos, Epub ahead of print, June 1st 2009, PMID: 19487252. Congratulations!
Graduate students Isabelle Laverdière and Olivier Eap were awarded FER (Université Laval) graduate scholarship (Master degree award). Congratulations!
Marie-Odile had her final thesis defense examination June 17, 2009. She is now a Ph.D. and got her degree from the faculty of Pharmacy. Congratulations Dre. Benoit-Biancamano !!! We wish you the best for your new career !
Graduate student Étienne Audet-Walsh won the 1st place in the graduate student poster award competition at the 66th annual congres of the Association of Faculties of Pharmacy of Canada, held in Halifax, Nova-Scotia (Canada), June 3rd to June 6th, 2009, with his poster “Genetic factors affecting the in vitro metabolism of the pure antiestrogen fulvestrant (Faslodex®)”. Congratulations!
Étienne Audet-Walsh participated to the 4th Annual Canadian Genetic Epidemiology & Statistical Genetics Meeting held in Harrison Hot Springs (British-Columbia, Canada), from May 27 to May 29, 2009.
Drs Éric Lévesque and Chantal Guillemette were awarded a grant for 3 years ($375 000) from the Canadian Institutes of Health Research (CIHR) for their application entitled “Hematopoietic stem cell (HCT) transplantation: Identification of key determinants of graft-versus-host disease”.
Dr Guillemette was awarded a grant for $162 500 for 5 years from the Canadian Institutes of Health Research (CIHR) for her application entitled “Pharmacogenomics of human UGT enzymes”. The application was ranked first in the Pharmaceutical Sciences committee. Congratulations to all the lab members’ whom contributed and continue to contribute to this project.
Drs Chantal Guillemette and Olivier Barbier are now offering Bioanalytical Services in the area of sex-steroid hormones and drug metabolism.
For inquiries, please contact René Bérubé at email@example.com
Graduate student Judith Bellemare was selected as a finalist for the poster presentations session at the 11th European Regional ISSX Meeting (17th -20th May, 2009, Lisbon). The title of her presentation is : Functional Co-expression of UGT1 Alternative Splice Isoforms and Evidence of Protein-protein Interaction. Congratulation for this selection Judith and good luck!
Graduate student Étienne was selected the ‘young researcher’ in the regional competition « Boîte à Sciences ». The purpose of this competition is to initiate young teenagers to scientific laboratories to promote science. Congratulations Étienne!
Judith had the chance to assist to the ‘International Workshop on High Throughput Technologies for Alternative Splicing’, in Valencia, Spain. She brought back new information to help her in Ph.D. program center on the study of alternative splicing in human UGT genes.
Graduate student Marie-Odile was awarded the ‘best oral presentation’ at the « Journée Phare », organised by the graduate students in pharmacology of the Sherbrooke University. Excellent presentation Marie-Odile; you very well represented the lab!
Part-time undergraduate students in the lab from January to May are Mélanie Rouleau, Isabelle Ouellette and Olivier Eap. We also welcome Christine Flageole, an undergraduate student from Université de Trois-Rivières, who will be working full time with us.
The CHUQ SIRIUS 2008 Research prize was awarded to Dr Chantal GuillemettePRIX CLINIQUE RECHERCHE at « Les grands prix Sirius du CHUQ » ceremony. Congratulations !
Welcome to our undergraduates’ for this session: Olivier Eap, Isabelle Ouellette and Mélanie Rouleau.
Johanie had her final thesis defense examination September 25, 2008. She is now a Ph.D. and got her degree from the faculty of Pharmacy. Congratulations Dre. Lepine !!! We wish you the best for your new career as a teacher!
Hugo had his final thesis defense examination August 28, 2008. He is now a Ph.D. and got his degree with ‘mention d’honneur’ (excellence) from the faculty of Pharmacy. Congratulations Dr.Girard !!!We wish you the greatest fun going back to medical school!!
The 12th International Workshop on Glucuronidation held on July 24 – 27th, 2008 in Quebec City was a great success! A total of 150 participants and their guests attended the meeting. we were happy to meet all of you and hope you enjoyed the meeting.
To learn more about this meeting please visit www.ugtworkshop.ulaval.ca
Chantal presented her talk entitled « Advances in the Pharmacogenomics of Phase II Drug Metabolizing Enzymes » at the World Conference on Clinical Pharmacology and Therapeutics held in Quebec City, July 27th – August 1st, 2008. She was also the co-chair of the session entitled ‘Pharmacogenomics in cancer’
Marie-Odile and Anne-Sophie presented a poster at the same meeting on their work on the metabolism of mycophenolate mofetil and presented on the epigenetic regulation of UGT1A1, respectively.
Congratulations to Judith for her 1st place in the graduate student oral presentation award competition at The 12th International Workshop on Glucuronidation and UGT enzymes held on July 24 – 27th, 2008 in Quebec City, Canada. She presented her work on the modulation of UGT enzymatic properties by splice forms of the UGT1 family.
Ph.D student Étienne Audet-Walsh joined the team today. Welcome Étienne !
Vincent Ménard is officially a Ph.D. student in the lab.
Hugo and Lyne publish their work on the susceptibility to colon cancer through a gene-diet interaction in Mutation Research.
Éric and Marie-Odile publish their work on the pharmacokinetics of mycophenolate mofetil in the Pharmacogenomics journal.
Congratulations to Judith for her 1st place in the graduate student poster award competition at the 10th European Regional ISSX Meeting in Vienna, Austria, May 11 – 13, 2008.She presented her work on the modulation of UGT enzymatic properties.
Congratulations to Dr Guillemette, she has been promoted to full professor at the Université Laval, Faculty of pharmacy.
Part-time student Oliver joined the team. Welcome Olivier !
Vincent and Jelena finished their master degree. Vincent is now a Ph.D student in the lab andJelena is now working in the industry.
Dr Chantal Guillemette win the 2008 YWCA Woman of Merit Award in the Science and Technology category. Congratulations !
Source : YWCA Quebec
Marie-Odile receive a graduate student research award from the Canadian Federation for University Women (CFUW). Congratulations !
Dr Eric Levesque, MD/Ph.D. received a prestigious Clinical Scientist phase I from the Canadian Institutes of Health Research(CIHR) and a scholarship from FRSQ.
Congratulations, we wish him a productive career as an independent investigator.
Vincent Ménard was awarded FRSQ (Québec province) Graduate Scholarships (Doctoral research award). Congratulations!
Congratulations to Hugo and Kim, on the arrival of their son, 7.9 pound Zack !
Anne-Sophie present her work on the epigenetic regulation of UGT1A1 at the Cancer Genomics and Epigenomics Conference, Taos, NM, USA, February 19-24, 2008.
Part-time student J-P is back in the lab !
Part-time student Melanie joined the team. Welcome Melanie !
Happy New Year !!!
Christmas dinner with all the members of the CHUL Research Center at Hotel Le Concorde.
Christmas dinner with all the members of the lab.
Hugo, Éric, Judith, Kim and Bertrand publish their work on the genetic diversity at the UGT1A locus in the Pharmacogenetics and Genomics Journal.
Hugo and Judith present their work on a new alternative splicing mecanism at the CSHL/WT meeting on Pharmacogenomics, Hinxton, UK, Oct 17-21, 2007.
Marie-Odile, Patrick and Éric publish their method validation on the measurement of MPA and its metabolites in Journal of Chromatography B.
Dr Guillemette Canada Research Chair Award (Junior level II) was renewed from April 2008 to March 2013. The Chair represents one of Canada’s highest distinctions in the field of research.
Dr Guillemette was recently elected to the Club de Recherche Clinique du Québec (CRCQ) Council.
Dr Guillemette was recently elected to the International Society for the Study of Xenobiotics (ISSX) Council by members of the Society. It is a 4-year term that will begin on January 1, 2008 and continue until the end of 2011. Council is responsible for the policies of the Society, approval of the Society’s budget and committee reports and for giving advice on matters of importance to the Society.
Isabelle Ouellette joined our lab today. She will work part-time with us while continuing her medical training at Laval University. Welcome Isabelle!
A new project was funded by the Cancer Research Society for 2 years and is entitled Identification of novel epigenetic targets in ovarian cancer by functional epigenomics. The project is directed by Dr Dimcho Bachvarov (principal investigator) and Dr Guillemette is a co-applicant.
Marie-Odile, Judith and Anne-Sophie were awarded Canada Graduate Scholarships (Doctoral research award) by the Canadian Institutes of Health Research.
Judith’s cat give birth to four lovely kittens (pictures coming soon).
Lyne is the ultimate champion of the 1st Purple Poker Tournament (PPT) held at Vincent’s house … well Vincent’s parents’ house.
Congratulations to Patrick and Marie-Claude, on the arrival of their daughter, 7.2 pound Camille!
CIHR March competition – The two grants that were submitted will be funded for 3 years.
Bertrand, Johanie, Jelena and Vincent publish their work on the pharmacogenomics of UGT1A3 in Pharmacogenetics and Genomics (July 2007)
NSERC support the lab for 5 years to study the physiological role of new UGT proteins.
Hugo, joined by Vincent, presents his work at the HUGO’s 12th Human Genome Meeting in Montreal, Canada, May 21-24, 2007.
Jelena, Marie-Odile and Vincent each receive a student award at the 7th Annual Research Meeting, Faculty of pharmacy, Laval University. Congratulations!
Johanie presents a poster at the AACR 2007 annual meeting held in Los-Angeles (CA), April 14-18, 2007.
Marie-Odile presents a poster at the ASCPT annual meeting held in Anaheim (CA), March 21-24, 2007.
Marie-Odile receives an award ‘Marie-Elder grant from the Canadian Federation of University Women (CFUW)’. Congratulations!
Anne-Sophie, Judith and Marie-Odile each receive a 3-years doctoral research award from the Canadian Institutes of Health Research (CIHR). Congratulations!
Jelena, Judith and Marie-Odile each receive a graduate student research award from the Fond de la Recherche en Santé du Québec (FRSQ). Congratulations!
Éric, Marie-Odile, Patrick and Olivier publish their work on the glucuronidation of the MPA in Clinical Pharmacology & Therapeutics.
Ph.D student Anne-Sophie Bélanger joined the team today. Welcome Anne-Sophie !
Éric, Hugo, Kim and Johanie publish their work on a new splicing event at the UGT1 locus in Hepatology.