Bioanalytical and Targeted Metabolomics services

Dre Chantal Guillemette is offering Bioanalytical and Targeted Metabolomics Services in the area of small molecules such as sex-steroid hormones and drug metabolism.

Examples of our most recent published work in this area:

Divergent Expression and Metabolic Functions of Human Glucuronosyltransferases through Alternative Splicing. Rouleau M, Tourancheau A, Girard-Bock C, Villeneuve L, Vaucher J, Duperré AM, Audet-Delage Y, Gilbert I, Popa I, Droit A, Guillemette C. Cell Rep. 2016 Sep 27;17(1):114-24

A chromatography/tandem mass spectrometry method for the simultaneous profiling of ten endogenous steroids, including progesterone, adrenal precursors, androgens and estrogens, using low serum volume. Caron P, Turcotte V, Guillemette C. Steroids. 2015 Dec;104:16-24

The UGT2B28 Sex-steroid Inactivation Pathway Is a Regulator of Steroidogenesis and Modifies the Risk of Prostate Cancer Progression. Belledant A, Hovington H, Garcia L, Caron P, Brisson H, Villeneuve L, Simonyan D, Têtu B, Fradet Y, Lacombe L, Guillemette C, Lévesque E. Eur Urol. 2016 Apr;69(4):601-9

Prediagnostic Sex Steroid Hormones in Relation to Male Breast Cancer Risk. Brinton LA, Key TJ, Kolonel LN, Michels KB, Sesso HD, Ursin G, Van Den Eeden SK, Wood SN, Falk RT, Parisi D, Guillemette C, Caron P, Turcotte V, Habel LA, Isaacs CJ, Riboli E, Weiderpass E, Cook MB. J Clin Oncol. 2015 Jun 20;33(18):2041-50

BCAT1 expression associates with ovarian cancer progression: possible implications in altered disease metabolism. Wang ZQ, Faddaoui A, Bachvarova M, Plante M, Gregoire J, Renaud MC, Sebastianelli A, Guillemette C, Gobeil S, Macdonald E, Vanderhyden B, Bachvarov D. Oncotarget. 2015 Oct 13;6(31):31522-43

Assay reproducibility of serum androgen measurements using liquid chromatography-tandem mass spectrometry.Trabert B, Xu X, Falk RT, Guillemette C, Stanczyk FZ, McGlynn KA. J Steroid Biochem Mol Biol. 2016 Jan;155(Pt A):56-62

Prediagnostic circulating inflammation markers and endometrial cancer risk in the prostate, lung, colorectal and ovarian cancer (PLCO) screening trial Trabert B, Eldridge RC, Pfeiffer RM, Shiels MS, Kemp TJ, Guillemette C, Hartge P, Sherman ME, Brinton LA, Black A, Chaturvedi AK, Hildesheim A, Berndt SI, Safaeian M, Pinto L, Wentzensen N. Int J Cancer. 2017 Feb 1;140(3):600-610

Fluoxetine and its active metabolite norfluoxetine disrupt estrogen synthesis in a co-culture model of the feto-placental unit Hudon Thibeault AA, Laurent L, Vo Duy S, Sauvé S, Caron P, Guillemette C, Sanderson JT, Vaillancourt C. Mol Cell Endocrinol. 2017 Feb 15;442:32-39.

Sex steroid hormones in relation to Barrett’s esophagus: an analysis of the FINBAR Study. Cook MB, Wood S, Hyland PL, Caron P, Drahos J, Falk RT, Pfeiffer RM, Dawsey SM, Abnet CC, Taylor PR, Guillemette C, Murray LJ, Anderson LA.Andrology. 2017 Mar;5(2):240-247. doi: 10.1111/andr.12314. Epub 2017 Feb 27.

For inquiries, please contact Dre Guillemette