Patrick Caron, B.Sc

Manager of the analytical chemistry platform
Bachelor in chemistry
Joined in : 2003

Nickname : Pat
Likes : disappearing during parties
Dislikes : the « one button » myth


List of publications


D’Amours O, Frenette G, Caron P, Belleannée C, Guillemette C, Sullivan R.  Evidences of Biological Functions of Biliverdin Reductase A in the Bovine Epididymis.  J Cell Physiol. 2016 May;231(5):1077-89. Epub 2015 Sep 30.

Caron P, Turcotte V, Guillemette C.  A chromatography/tandem mass spectrometry method for the simultaneous profiling of ten endogenous steroids, including progesterone, adrenal precursors, androgens and estrogens, using low serum volume. Steroids. 2015 Dec;104:16-24. Epub 2015 Aug 6

Belledant A, Hovington H, Garcia L, Caron P, Brisson H, Villeneuve L, Simonyan D, Têtu B, Fradet Y, Lacombe L, Guillemette C, Lévesque E.  The UGT2B28 Sex-steroid Inactivation Pathway Is a Regulator of Steroidogenesis and Modifies the Risk of Prostate Cancer Progression. Eur Urol. 2016 Apr;69(4):601-9. Epub 2015 Jul 26.

Margaillan G, Rouleau M, Klein K, Fallon JK, Caron P, Villeneuve L, Smith PC, Zanger UM, Guillemette C.
Multiplexd Targeted Quantitative Proteomics Predicts Hepatic Glucuronidation Potentiel.  Drug Metab Dispos. 2015 Sep;43(9):1331-5.

Brinton LA, Key TJ, Kolonel LN, Michels KB, Sesso HD, Ursin G, Van Den Eeden SK, Wood SN, Falk RT, Parisi D, Guillemette C, Caron P,Turcotte V, Habel LA, Isaacs CJ, Riboli E, Weiderpass E, Cook MB.
Prediagnostic Sex Steroid Hormones in Relation to Male Breast Cancer Risk.  J Clin Oncol. 2015 Jun 20;33(18):2041-50.

Margaillan G, Rouleau M, Fallon JK, Caron P, Villeneuve L, Turcotte V, Smith PC, Joy MS, Guillemette C.
Quantitative Profiling of Human Renal UGTs and Glucuronidation Activity: A Comparison of Normal and Tumoral Kidney Tissues.  Drug Metab Dispos. 2015 Apr;43(4):611-9.

Laverdiere I, Flageole C, Audet-Walsh E, Caron P, Fradet Y, Lacombe L, Levesque E, Guillemette C. The UGT1 locus is a determinant of prostate cancer recurrence after prostatectomy.   Endocr Relat Cancer. 2015 Feb;22(1):77-85.

Cook MB1, Wood SN1, Cash BD2, Young P2, Acosta RD2, Falk RT1, Pfeiffer RM1, Hu N1, Su H1, Wang L1, Wang C1, Gherman B3, Giffen C4, Dykes C2, Turcotte V5, Caron P5, Guillemette C5, Dawsey SM1, Abnet CC1, Hyland PL1, Taylor PR1 . Association Between Circulating Levels of Sex Steroid Hormones and Barrett’s Esophagus in Men: a Case-Control Analysis. Clin Gastroenterol Hepatol. 2014 Aug

Levesque E, Laverdiere I, Audet-Walsh E, Caron P, Rouleau M, Fradet Y, Lacombe L, Guillemette C. Steroidogenic Germline Polymorphism Predictors of Prostate Cancer Progression in the Estradiol Pathway. Clin Cancer Res. 2014 Mar 28.

Levesque E, Laverdiere I, Lacombe L, Caron P, Rouleau M, Turcotte V, Tetu B, Fradet Y, Guillemette C. Importance of 5α-Reductase Gene Polymorphisms on Circulating and Intraprostatic Androgens in Prostate Cancer. Clin Cancer Res. 2014 Feb 1;20(3):576-84. Epub 2013 Nov 25.
Grosse L, Paquet S, Caron P, Fazli L, Rennie PS, Belanger A, Barbier O. Androgen glucuronidation: an unexpected target for androgen deprivation therapy with prognosis and diagnostic implications. Cancer Res. 2013 Dec 1;73(23):6963-71.

Martin Perreault, Andrzej Bialek, Jocelyn Trottier, Mélanie Verreault, Patrick Caron, Piotr Milkiewicz, Olivier Barbier. Role of glucuronidation for hepatic detoxification and uriny elimination of toxic bile acids during biliary obstruction. Plos One 2013 Nov 14;8(11)

Trottier J, Perreault M, Rudkowska I, Levy C, Dallaire-Theroux A, Verreault M, Caron P, Staels B, Vohl MC, Straka RJ, Barbier O.
Profiling serum bile acid glucuronides in humans: gender divergences, genetic determinants and response to fenofibrate. Clin Pharmacol Ther. 2013 Jun 12.

Perreault M, Gauthier-Landry L, Trottier J, Verreault M, Caron P, Finel M, Barbier O. The Human UDP-glucuronosyltransferase UGT2A1 and UGT2A2 Enzymes Are Highly Active in Bile Acid Glucuronidation. Drug Metab Dispos. 2013 Jun 11.

Grosse L, Campeau AS, Caron S, Morin FA, Meunier K, Trottier J, Caron P, Verreault M, Barbier O. Enantiomer Selective Glucuronidation of the Non-Steroidal Pure Anti-Androgen Bicalutamide by Human Liver and Kidney: Role of the Human UDP-Glucuronosyltransferase (UGT)1A9 Enzyme. Basic Clin Pharmacol Toxicol. 2013 Mar 25.

Lévesque É, Huang SP, Audet-Walsh É, Lacombe L, Bao BY, Fradet Y, Laverdière I, Rouleau M, Huang CY, Yu CC, Caron P, Guillemette C. Molecular markers in key steroidogenic pathways, circulating steroid levels, and prostate cancer progression. Clin Cancer Res. 2013 Feb 1;19(3):699-709.

Laverdière I, Caron P, Couture F, Lévesque E, Guillemette C. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for monitoring drug exposure in hematopoietic stem cell transplant recipients. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Feb 15;885-886:131-7.

Trottier J, Białek A, Caron P, Straka RJ, Heathcote J, Milkiewicz P, Barbier O. Metabolomic profiling of 17 bile acids in serum from patients with primary biliary cirrhosis and primary sclerosing cholangitis: A pilot study. Dig Liver Dis. 2012 Apr;44(4):303-10

Laverdière I, Caron P, Couture F, Guillemette C, Levesque E. Liquid chromatography-Coupled Tandem Mass Spectrometry based Assay to Evaluate Inosine-5′-monophosphate Dehydrogenase Activity in Peripheral Blood Mononuclear Cells from Stem Cell Transplant Recipients. Anal Chem. 2012 Jan 3;84(1):216-23

Trottier J, Caron P, Straka RJ, Barbier O. Profile of serum bile acids in noncholestatic volunteers: gender-related differences in response to fenofibrate. Clin Pharmacol Ther. 2011 Aug;90(2):279-86. doi: 10.1038/clpt.2011.124.

Trottier J, Białek A, Caron P, Straka RJ, Milkiewicz P, Barbier O. Profiling circulating and urinary bile acids in patients with biliary obstruction before and after biliary stenting PLoS One. 2011;6(7):e22094.

Nadeau G, Bellemare J, Audet-Walsh E, Flageole C, Huang SP, Bao BY, Douville P, Caron P, Fradet Y, Lacombe L, Guillemette C, Lévesque E. Deletions of the Androgen-Metabolizing UGT2B Genes Have an Effect on Circulating Steroid Levels and Biochemical Recurrence after Radical Prostatectomy in Localized Prostate Cancer. J Clin Endocrinol Metab. 2011 Sep;96(9):E1550-7

Laverdiere I, Caron P, Harvey M, Levesque E, Guillemette C. In vitro investigation of human UDP-glucuronosyltransferase isoforms responsible for tacrolimus glucuronidation: predominant contribution of UGT1A4. Drug Metab Dispos. 2011 Jul;39(7):1127-30

Audet-Walsh E, Lépine J, Grégoire J, Plante M, Caron P, Têtu B, Ayotte P, Brisson J, Villeneuve L, Bélanger A, Guillemette C. Profiling of Endogenous Estrogens, Their Precursors, and Metabolites in Endometrial Cancer Patients: Association with Risk and Relationship to Clinical Characteristics. J Clin Endocrinol Metab. 2011 Feb;96(2):E330-9

Giton F, Patrick C, René B, Alain B, Olivier B, Fiet J. Plasma estrone sulfate assay in men: comparison of Radioimmunoassay, Mass Spectrometry coupled to Gas Chromatography (GC-MS), and Liquid Chromatography – Tandem Mass Spectrometry (LC-MS/MS). Clinica Chimica Acta. 2010 Sep 6;411(17-18):1208-13

Lépine J, Audet-Walsh E, Grégoire J, Têtu B, Plante M, Ménard V, Ayotte P, Brisson J, Caron P, Villeneuve L, Bélanger A, Guillemette C. Circulating Estrogens in Endometrial Cancer Cases and Their Relationship with Tissular Expression of Key Estrogen Biosynthesis and Metabolic Pathways. J Clin Endocrinol Metab. June 2010, 95(6) : 2689-2698

Caron P, Audet-Walsh E, Lépine J, Bélanger A, Guillemette C. Profiling Endogenous Serum Estrogen and Estrogen-Glucuronides by Liquid Chromatography-Tandem Mass Spectrometry. Anal. Chem. 2009, 81, 10143–10148

Benoit-Biancamano MO, Adam JP, Bernard O, Court MH, Leblanc MH, Caron P, Guillemette C.A pharmacogenetics study of the human glucuronosyltransferase UGT1A4. Pharmacogenetics and Genomics. 19(12):945-954, December 2009

Trottier J, El Husseini D, Perreault M, Pâquet S, Caron P, Bourassa S, Verreault M, Inaba TT, Poirier GG, Bélanger A, Guillemette C, Trauner M, Barbier O.The human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates norursodeoxycholic acid into a C23-ester glucuronide in the liver. J Biol Chem. 2010 Jan 8;285(2):1113-21

Verreault M, Kaeding J, Caron P, Trottier J, Grosse L, Houssin E, Pâquet S, Perreault M, Barbier O. Regulation of endobiotics glucuronidation by ligand-activated transcription factors: physiological function and therapeutic potential. Drug Metab Rev. 2010; 42(1): 106–118

Tojcic J, Benoit-Biancamano MO, Court MH, Straka RJ, Caron P, Guillemette C.
In vitro glucuronidation of fenofibric acid by human UGTs and liver microsomes.Drug Metab Dispos. 2009 Nov;37(11):2236-43

Belanger AS, Caron P, Harvey M, Zimmerman PA, Mehlotra RK, Guillemette C.
Glucuronidation of the antiretroviral drug efavirenz (EFV) by UGT2B7 and an in vitro investigation of drug-drug interaction with zidovudine (AZT). Drug Metab Dispos. 2009 Sep;37(9):1793-6

Barbier O, Trottier J, Kaeding J, Caron P, Verreault M. Lipid-activated transcription factors control bile acid glucuronidation.Mol Cell Biochem.2009 Jun;326(1-2):3-8.

Marie-Odile Benoit-Biancamano MO, Connelly J, Villeneuve L, Caron P, Guillemette C. Deferiprone glucuronidation by human tissues and recombinant UGT1A6: an in vitro investigation of genetic and splice variants. Drug Metab Dispos. 2009 Feb; 37(2):322-9.

Kaeding J, Bélanger J, Caron P, Verreault M, Bélanger A, Barbier O. Calcitrol (1{alpha},25-dihydroxyvitamin D3) inhibits androgen glucuronidation in prostate cancer cells. Mol Cancer Ther. 2008 Feb;7(2):380-90.

Kaeding J., Bouchaert E., Bélanger J., Caron P., Chouinard S, Verreault M., Larouche O, Pelletier G, Staels B., Bélanger A. and Barbier O. Activators of the farnesoid X-receptor negatively regulate androgen glucuronidation in human prostate cancer LNCaP cells. Biochem J. 2008 Mar 1;410(2):245-53.

Marie-Odile Benoit-Biancamano, Patrick Caron, Éric Lévesque, Robert Delage, Félix Couture, Chantal Guillemette
Sensitive high-performance liquid chromatography-tandem mass spectrometry method for quantitative analysis of mycophenolic acid and its glucuronide metabolites in human plasma and urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Oct 15;858(1-2):159-67.

Éric Lévesque, Robert Delage, Marie-Odile Benoit-Biancamano, Patrick Caron, Olivier Bernard, Félix Couture and Chantal Guillemette. The impact of UGT1A8, UGT1A9, and UGT2B7 genetic polymorphisms on the pharmacokinetic profile of mycophenolic acid after a single oral dose in healthy volunteers. Clin Pharmacol Ther. 2007 Mar;81(3):392-400

Trottier J., M. Verreault, J. Bélanger, J. Kaeding, P. Caron, T. T. Inaba, and Barbier O. The human UDP-glucuronosyltransferase(UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver. Hepatology. 2006 Nov 44(5): 1158-1170

Verreault M., K. Senekeo-Effenberger, J. Trottier, J. A. Bonzo, J. Bélanger, J. Kaeding, B. Staels, P. Caron, R. H. Tukey and Barbier O. The liver X-Receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice. Hepatology. 2006 Aug;44(2):368-78.

Hugo Girard, Lyne Villeneuve, Michael H. Court, Louis-Charles Fortier, Patrick Caron, Qin Hao, Lisa L. von Moltke, David J. Greenblatt, Chantal Guillemette. The novel UGT1A9 intronic I399 polymorphism appears as a predictor of SN-38 glucuronidation levels in the liver. Drug Metabolism and Disposition, 2006 Jul; 34(7):1220-8.

Caron P., J. Trottier, M. Verreault, J. Bélanger, J. Kaeding and Barbier O. Enzymatic production of bile Acid glucuronides used as analytical standards for liquid chromatography-mass spectrometry analyses. Mol Pharm. 2006 May-Jun;3(3):293-302

Hugo Girard, Jean Thibaudeau, Michael H. Court, Louis-Charles Fortier, Lyne Villeneuve, Patrick Caron, Lisa L. vonMoltke, David J.Greenblatt, Chantal Guillemette. UGT1A1 polymorphisms are important determinants of dietary carcinogen detoxification in the liver. Hepatology. 2005 Aug;42(2):448-57.