UGT2B4 allele nomenclature (view change log)

 

Allele naming

Protein

Nucleotide change

Amino acid change

Effect

Enzyme activity

Genbank

Reference

Notes

In vivo

In vitro

UGT2B4*1a

UGT2B4.1

 

 

Wild-type

 Normal

Normal 

Y003171;
AJ005162

Jackson MR et al

 

UGT2B4*1b

UGT2B4.1

IVS4+61(T>C)

 

 

 

 

N/A

Saeki et al

 

UGT2B4*1c

UGT2B4.1

-1255(A>C)/-162(T>G)/IVS4+61(T>C)

 

 

 

 

N/A

Saeki et al

 

UGT2B4*1d

UGT2B4.1

IVS4+161_162(ins TGATAA)/1212(A>T)

A404A

Silent

 

 

N/A

Saeki et al

 

UGT2B4*1e

UGT2B4.1

-1255(A>C)/-162(T>G)/IVS3-13_6(delT)/IVS5-83(G>C)

 

 

 

 

N/A

Saeki et al

 

UGT2B4*1f

UGT2B4.1

IVS4+61(T>C)/IVS4+146(G>A)

 

 

 

 

N/A

Saeki et al

 

UGT2B4*1g

UGT2B4.1

-1255(A>C)/-162(T>G)/IVS4+61(T>C)/ IVS4+146(G>A)

 

 

 

 

N/A

Saeki et al

 

UGT2B4*1h

UGT2B4.1

-162(T>G)/IVS4+61(T>C)

 

 

 

 

N/A

Saeki et al

 

UGT2B4*1j

UGT2B4.1

IVS4+145(C>T)/IVS4+161_162(ins TGATAA)

 

 

 

 

N/A

Saeki et al

 

UGT2B4*1k

UGT2B4.1

-1255(A>C)/-162(T>G)/IVS4+161_162(ins TGATAA)

 

 

 

 

N/A

Saeki et al

 

UGT2B4*1l

UGT2B4.1

-1255(A>C)/-162(T>G)/IVS5-83(G>C)

 

 

 

 

N/A

Saeki et al

 

UGT2B4*1m

UGT2B4.1

-1255(A>C)/-162(T>G)/IVS3-13_6(delT)

 

 

 

 

N/A

Saeki et al

 

UGT2B4*1n

UGT2B4.1

-162(T>G)/IVS4+146(G>A)/IVS4+161_162(ins TGATAA)/Exon5+1212(A>T)

A404A

Silent

 

 

N/A

Saeki et al

 

UGT2B4*1p

UGT2B4.1

IVS4+145(C>T)/IVS4+161_162(ins TGATAA)/1212(A>T)

A404A

Silent

 

 

N/A

Saeki et al

 

UGT2B4*1q

UGT2B4.1

1212(A>T)/IVS5-83(G>C)

A404A

Silent

 

 

N/A

Saeki et al

 

UGT2B4*1r

UGT2B4.1

IVS4+161_162(ins TGATAA)

 

 

 

 

NT_077444.2

Saeki et al

Renamed from UGT1A6*1a

UGT2B4*1s

UGT2B4.1

IVS5-83(G>C)

 

 

 

 

N/A

Saeki et al

Renamed from UGT1A6*1i2

UGT2B4*1t

UGT2B4.1

IVS2+44(C>T)/IVS4+61(T>C)

 

 

 

 

N/A

Saeki et al

Renamed from UGT1A6*1o2

UGT2B4*2a

UGT2B4.2

1374(T>A)/1375(C>A)

D458E

 

Normal

(Levesque E et al)

 

AF064200

Levesque E et al

 

UGT2B4*2b

UGT2B4.2

-1255(A>C)/-162(T>G)/IVS4+61(T>C)/IVS4+109_114(delATAAAA)/IVS5-52(C>T)/1374(T>A)/1375(C>A)

D458E/R459R

 

 

 

N/A

Saeki et al

Renamed from UGT2B4*2a

UGT2B4*3 

UGT2B4.3

325(T>C)/1186(T>C)

F109L/F369L

 

No activity with hyodeoxycholic acid

(Jin CJ et al)

 

AF081793

Jin CJ et al

Formerly UGT2B11

UGT2B4*4

UGT2B4.4

IVS4+162_163(ins TGATAA)/1364(A>G)

K455R

 

 

 

N/A

Saeki et al

Named *455R by the author

UGT2B4*5

UGT2B4.5

IVS4+162_163(ins TGATAA)/1212(A>T)/1531(T>C)

A404A/C511R

 

 

 

N/A

Saeki et al

Named *511R by the author

 UGT2B4*6

UGT2B4.6

1372(G>C)/1374(T>A)

D458Q

 

 

 

N/A

Riedy M et al

 

 

1 Y00317 has been resequenced and shown to be identical to AJ005162. See the Levesque et al paper or the alignment for details.

2 Alleles were renamed since the letters i and o are excluded in the UGT Allele Nomenclature because of indexing problems.

N/A : data not available in the manuscript