UGT1A6 allele nomenclature (view change log)

Allele naming	Protein	Nucleotide change	Amino acid change	Effect	Enzyme activity		Genbank	References	Notes
					In vivo	In vitro
UGT1A6 *1a	UGT1A6.1			Wild-type	Normal	Normal	AF297093
UGT1A6*1b	UGT1A6.1	-1535(G>A)/ -427(G>C)					N/A	Krishnaswamy et al., 2005
UGT1A6*1c	UGT1A6.1	-427(G>C)					N/A	Krishnaswamy et al., 2005
UGT1A6*1d	UGT1A6.1	-1535(G>A)/ -1377(G>A)/ -427(G>C)					N/A	Krishnaswamy et al., 2005
UGT1A6 *1e	UGT1A6.1	105(C>T)	D^35D	Silent			N/A	Saeki M, 2005	Renamed from UGT1A6*1b
UGT1A6 *1f	UGT1A6.1	IVS1+120(A>G)					N/A	Saeki et al., 2005	Renamed from UGT1A6*1c
UGT1A6 *1g	UGT1A6.1	IVS1+142(C>T)					N/A	Saeki et al., 2005	Renamed from UGT1A6*1d
UGT1A6*2a	UGT1A6.2	19(T>G)/315(A>G)/541(A>G)/552(A>C)/ IVS1+130(G>T)	S^7A/L^105L/T^181A/R^184S			High activity (Krishnaswamy et al., 2005) High activity (Nagar et al., 2004)	N/A	Saeki et al., 2005
UGT1A6*2c	UGT1A6.2	19(T>G)/315(A>G)/541(A>G)/552(A>C)/ IVS1+109(C>T)/IVS1+130(G>T)	S^7A/L^105L/T^181A/R^184S				N/A	Saeki et al., 2005
UGT1A6*2d	UGT1A6.2	19(T>G)/279(A>G)/315(A>G)/541(A>G)/ 552(A>C)/IVS1+130(G>T)	S^7A/S^93S/L^105L/T^181A/R^184S				N/A	Saeki et al., 2005
UGT1A6*2e	UGT1A6.2	-1710(C>G)/ -1377(G>A)/ -1310 (del AGGAG)/-652(G>A)/19(T>G)/ 315(A>G)/541(A>G)/552(A>C)	S^7A/L^105L/T^181A/R^184S				N/A	Krishnaswamy et al., 2005
UGT1A6*3a	UGT1A6.3	-1710(C>G)/ -1377(G>A)/ -1310 (del AGGAG)/-652(G>A)/ 19(T>G)	S^7A				N/A	Krishnaswamy et al., 2005
UGT1A6*3b	UGT1A6.3	-1710(C>G)/ -1377(G>A)/ -1310 (del AGGAG)/-652(G>A)/ 19(T>G)/ 315(A>G)	S^7A/L^105L				N/A	Krishnaswamy et al., 2005
UGT1A6 *4a	UGT1A6.4	19(T>G)/315(A>G)/552(A>C)	S^7A/L^105L/R^184S				N/A	Nagar et al., 2004
UGT1A6 *4b	UGT1A6.4	19(T>G)/315(A>G)/552(A>C)/627(G>T)	S^7A/L^105L/R^184S/V^209V				N/A	Saeki et al., 2005
UGT1A6 *4c	UGT1A6.4	-1710(C>G)/ -1377(G>A)/-1310 (del AGGAG)/-652(G>A)/ 19(T>G)/ 315(A>G)/ 552(A>C)	S^7A/L^105L/R^184S				N/A	Krishnaswamy et al., 2005
UGT1A6*5	UGT1A6.5	541(A>G)	T^181A				N/A	Krishnaswamy et al., 2005
UGT1A6*6	UGT1A6.6	19(T>G)/308(C>A)/315(A>G)/541(A>G)/552(A>C)/IVS1+130(G>T)	S^7A/S^103X/L^105L/T^181A/R^184S				N/A	Saeki et al., 2005	Renamed from UGT1A6*5
UGT1A6*7	UGT1A6.7	19(T>G)/269(G>A)/315(A>G)/541(A>G)/552(A>C)/IVS1+130(G>T)	S^7A/R^90H/L^105L/T^181A/R^184S				N/A	Saeki et al., 2005
UGT1A6*8	UGT1A6.8	541(A>G)/552(A>C)	T^181A/R^184S			Low activity (Ciotti et al., 1997) High activity (Krishnaswamy et al., 2005)	N/A	Ciotti et al., 1997
UGT1A6*9	UGT1A6.9	552(A>C)	R^184S				N/A	Ciotti et al., 1997

N/A : data not available in the manuscript.