UGT1A3 allele nomenclature (view change log)

Allele naming	Protein	Promoter nucleotide change	Coding nucleotide change	Amino acid change	Transcription level	Enzyme activity		Genbank	References	Notes
						In vivo	In vitro
UGT1A3*1a	UGT1A3.1	Reference sequence	Reference sequence	Reference sequence	Normal	Normal	Normal	NM_019093 AY724451
UGT1A3*1b	UGT1A3.1	Reference sequence	537(T>C)	D^179D	Normal (Caillier B, 2007)				Caillier B, 2007
UGT1A3*1c	UGT1A3.1	Reference sequence	477(A>G)	A^159A	Normal (Caillier B, 2007)				Caillier B, 2007
UGT1A3*1d	UGT1A3.1	Reference sequence	81(G>A)	E^27E	Normal (Caillier B, 2007)				Caillier B, 2007
UGT1A3*1e	UGT1A3.1	-581(C>T)	Reference sequence	Reference sequence	Low (Caillier B, 2007)				Caillier B, 2007
UGT1A3*1f	UGT1A3.1	-581(C>T)	81(G>A)	E^27E	Low (Caillier B, 2007)				Caillier B, 2007
UGT1A3*2a	UGT1A3.2	-758(A>G)/-751(T>C)/-581(C>T)/-204(A>G)/-66(T>C)	31(T>C)/81(G>A)/140(T>C)/ 477(A>G)	W^11R/ E^27E/ V^47A/A^159A	Low (Caillier B, 2007)		Normal (Caillier B, 2007)	AF465194 AY724454	Ehmer U, 2004 Caillier B, 2007
UGT1A3*2b	UGT1A3.2	-758(A>G)/-751(T>C)/-581(C>T)/-204(A>G)/-148(T>C)/-66(T>C)	31(T>C)/81(G>A)/140(T>C)/477(A>G)	W^11R/E^27E/V^47A/A^159A	Low (Caillier B, 2007)		High (Iwai M, 2004)	AB120361	Iwai M, 2004 Caillier B, 2007
UGT1A3*2c	UGT1A3.2	-758(A>G)/-751(T>C)/-581(C>T)/-553(G>A)/-204(A>G)/-66(T>C)	31(T>C)/81(G>A)/140(T>C)/234(A>G)/477(A>G)	W^11R/E^27E/V^47A/T^78T/A^159A	Low (Caillier B, 2007)				Caillier B, 2007
UGT1A3*2d	UGT1A3.2	-758(A>G)/-751(T>C)/-581(C>T)/-553(G>A)/-204(A>G)/-66(T>C)	31(T>C)/81(G>A)/140(T>C)/477(A>G)	W^11R/E^27E/V^47A/A^159A	Low (Caillier B, 2007)				Caillier B, 2007
UGT1A3*2e	UGT1A3.2	Reference sequence	31(T>C)/81(G>A)/140(T>C)	W^11R/E^27E/V^47A	Low (Caillier B, 2007)				Caillier B, 2007
UGT1A3*3a	UGT1A3.3	-758(A>G)/-581(C>T)/-204(A>G)/-66(T>C)	31(T>C)/81(G>A)/477(A>G)	W^11R/E^27E/A^159A	Low (Caillier B, 2007)		Normal (Caillier B, 2007)	AF465193 AY724452	Ehmer U, 2004 Caillier B, 2007
UGT1A3*3b	UGT1A3.3	N/A	31(T>C)/81(G>A)/477(A>G)	W^11R/E^27E/A^159A	N/A			AB120359	Iwai M, 2004
UGT1A3*4a	UGT1A3.4	N/A	133(C>T)	R^45W	N/A		Low (Caillier B, 2007)	AB120362	Iwai M, 2004
UGT1A3*5a	UGT1A3.5	N/A	17(A>G)/31(T>C)/81(G>A)/477(A>G)	Q^6R/W^11R/E^27E/A^159A	N/A		Intermediate (Caillier B, 2007)	AB120360	Iwai M, 2004
UGT1A3*6a	UGT1A3.6	-758(A>G)/-751(T>C)/-581(C>T)/-204(A>G)/-66(T>C)	31(T>C)/81(G>A)/140(T>C)/477(A>G)/808(A>G)	W^11R/E^27E/V^47A/A^159A/M^270V	Low (Caillier B, 2007)		Low (Caillier B, 2007)	AY724455	Caillier B, 2007
UGT1A3*7a	UGT1A3.7	-758(A>G)/-751(T>C)/-581(C>T)/-204(A>G)/-66(T>C)	328(T>A)	F^110I	Low (Caillier B, 2007)		Intermediate (Caillier B, 2007)	AY724450	Caillier B, 2007	Hypothetical allele (n=1/498)
UGT1A3*8a	UGT1A3.8	Reference sequence	473(C>T)	A^158V	Normal (Caillier B, 2007)		Low (Caillier B, 2007)	DQ408604	Caillier B, 2007
UGT1A3*9a	UGT1A3.9	-758(A>G)/-751(T>C)/-581(C>T)/-204(A>G)/-66(T>C)	31(T>C)/81(G>A)/477(A>G)/622(A>C)	W^11R/E^27E/A^159A/M^208L	Low (Caillier B, 2007)		Intermediate (Caillier B, 2007)	AY724453	Caillier B, 2007	Hypothetical allele (n=1/498)
UGT1A3*10a	UGT1A3.10	Reference sequence	140(T>C)	V^47A	Normal (Caillier B, 2007)		Intermediate (Caillier B, 2007)		Caillier B, 2007
UGT1A3*10b	UGT1A3.10	-581(C>T)	140(T>C)	V^47A	Low (Caillier B, 2007)				Caillier B, 2007
UGT1A3*11a	UGT1A3.11	N/A	31(T>C)/81(G>A)/140(T>C)/342(G>A)/477(A>G)	W^11R/E^27E/V^47A/M^114I/A^159A	N/A		Intermediate (Caillier B, 2007)		Thomas SS, 2006

Changes made on the last update are in red (2007-09-04).

N/A : data not available in the manuscript.