UGT1A10 allele nomenclature (view change log)

 

Allele naming

Protein

Nucleotide change

Amino acid change

Effect

Enzyme activity

Genbank

Reference

Notes

In vivo

In vitro

UGT1A10*1a

 

UGT1A10.1

 

 

 Wild-type

 

 Normal

U39550,

AF297093

 

 

UGT1A10*1b

UGT1A10.1

126(G>A)

Q42Q

 

 

 

N/A

Elahi et al.

Renamed from

UGT1A10*1a

UGT1A10*1c

UGT1A10.1

597(T>C)

H199H

 

 

 

N/A

Elahi et al.

Renamed from

UGT1A10*1b

UGT1A10*1d

UGT1A10.1

597(T>C)/693(C>T)

H199H/A231A

 

 

 

N/A

Elahi et al.

Renamed from

UGT1A10*1c

UGT1A10*2a

UGT1A10.2

415(G>A)

E139K

 

 

 

N/A

Elahi et al.

 

UGT1A10*3a

UGT1A10.3

719(C>T)

T240M

 

 

 

N/A

Elahi et al.

 

UGT1A10*3b

UGT1A10.3

693(C>T)/ 719(C>T)

A231A/T240M

 

 

 

N/A

Elahi et al.

Renamed from

UGT1A10*3a

UGT1A10*4a

UGT1A10.4

730(C>A)

L244I

 

 

 

N/A

Elahi et al.

 

UGT1A10*4b

UGT1A10.4

693(C>T)/ 730(C>A)

A231A/L244I

 

 

 

N/A

Elahi et al.

Renamed from

UGT1A10*4a

UGT1A10*4c

UGT1A10.4

597(T>C)/ 693(C>T)/730(C>A)

H199H/ A231A/L244I

 

 

 

N/A

Elahi et al.

Renamed from

UGT1A10*4b

UGT1A10*5

 

UGT1A10.5

177(G>A)

M59I

 

 

No change

(Jinno et al.)

N/A

Saeki et al.,

Jinno et al.

 

UGT1A10*6

 

UGT1A10.6

605(C>T)

T202I

 

 

Reduced by 50%

(Jinno et al.)

N/A

Saeki et al.,

Jinno et al.

 

UGT1A10*7

 

UGT1A10.7

622 (T>C)

I211T

 

 

No activity

(Martineau et al.)

N/A

Martineau et al.

 

 

N/A : Data not available in the manuscript.